Rivervest Venture Partners
SEC exempt reporting adviser (venture capital exemption).
- Website
- HTTP://WWW.RIVERVEST.COM
- HQ
- MO
RiverVest Venture Partners is a venture capital firm that builds life science companies to address significant unmet needs of patients. It was formed in September 2000 and raised its first fund, which later produced commercial products treating patients. The firm also runs the 3x5 Special Opportunity Fund, a joint venture with Arnerich Massena, which makes a concentrated portfolio of later-stage life science and natural resource and infrastructure investments. RiverVest Fund II launched with the same strategy.
New fund likely raising soon
The firm's newest fund is 4 to 7 years past its first sale and no newer Form D has been filed.
01 · Says / Does
| Tag | Says | Does | Historically (to 2020) |
|---|---|---|---|
| Stages | Not stated | Not enough dated deals | Series A, Series B, Growth |
| Sectors | Biotech, Medical devices | Not enough dated deals | Biotech, Healthtech, Medical devices, Manufacturing, Life sciences and research tools |
| Regions | Not stated | Not enough dated deals | CA, OH |
Says: what the firm's funds state. Does: from 1 dated deal in the last 24 months.
Historical focus (through 2020), derived from historical deal data.
| Year | Deals | Top sectors |
|---|---|---|
| 2000 | 1 | Healthtech |
| 2001 | 1 | Healthtech, Manufacturing |
| 2003 | 2 | Healthtech, Medical devices |
| 2004 | 2 | Healthtech, Biotech, Medical devices |
| 2005 | 1 | Biotech, Healthtech, Life sciences and research tools |
| 2006 | 2 | Biotech, Healthtech, Manufacturing |
| 2007 | 2 | Healthtech, Biotech, Medical devices |
| 2008 | 2 | Biotech, Medical devices, Healthtech |
| 2009 | 1 | Biotech, Manufacturing, Medical devices |
| 2010 | 5 | Biotech, Healthtech, Manufacturing |
| 2011 | 2 | Biotech, Life sciences and research tools, Healthtech |
| 2012 | 2 | Biotech, Energy, Hardware |
| 2013 | 4 | Biotech, Healthtech, Life sciences and research tools |
| 2014 | 7 | Biotech, Healthtech, Manufacturing |
| 2015 | 2 | Biotech, Healthtech |
| 2016 | 3 | Biotech, Healthtech, Life sciences and research tools |
| 2017 | 6 | Biotech, Healthtech, Medical devices |
| 2018 | 5 | Biotech, Healthtech, Life sciences and research tools |
| 2019 | 4 | Biotech, Healthtech |
| 2020 | 5 | Biotech, Healthtech, Life sciences and research tools |
Stage mix over time
- Pre-seed
- Seed
- Series A
- Series B
- Growth
| Year | Pre-seed | Seed | Series A | Series B | Growth |
|---|---|---|---|---|---|
| 2010 | 0 | 0 | 0 | 1 | 2 |
| 2011 | 0 | 0 | 2 | 0 | 0 |
| 2012 | 0 | 0 | 1 | 0 | 1 |
| 2013 | 0 | 0 | 1 | 1 | 1 |
| 2014 | 0 | 0 | 2 | 2 | 2 |
| 2015 | 0 | 0 | 1 | 1 | 0 |
| 2016 | 0 | 0 | 2 | 0 | 1 |
| 2017 | 0 | 0 | 2 | 2 | 2 |
| 2018 | 0 | 0 | 3 | 2 | 0 |
| 2019 | 0 | 0 | 1 | 3 | 0 |
| 2020 | 0 | 0 | 1 | 3 | 1 |
| 2021 | 0 | 0 | 0 | 0 | 0 |
| 2022 | 0 | 0 | 0 | 0 | 0 |
| 2023 | 0 | 0 | 0 | 0 | 0 |
| 2024 | 0 | 0 | 0 | 0 | 0 |
| 2025 | 0 | 0 | 0 | 0 | 0 |
| 2026 | 0 | 0 | 0 | 0 | 0 |
02 · Fund history
| Fund | Year | Size | Status |
|---|---|---|---|
| RiverVest Venture Fund V, L.P. | 2020 | $275M (Form D) | Follow-ons only |
03 · People across funds
- Jay Schmelter, Manager of the GP LLC.
RiverVest Venture Fund V, L.P. (Named on Form D)
- John McKearn, Manager of the GP LLC.
RiverVest Venture Fund V, L.P. (Named on Form D)
- Niall O'Donnell, Manager of the GP LLC.
RiverVest Venture Fund V, L.P. (Named on Form D)
- Isaac Zike, Managing Director
- Jay W. Schmelter, Co-Founder & Managing Director
- Karen Spilizewski, Managing Director
- Michael Berman, Consultant and Venture Partner
- Nafise Masoumi, Principal
- Pascal Krotee, Principal
- Tom Melzer, Co-Founder and Managing Director
- Derek Rapp, Managing Director
On the team page, not linked to a fund
04 · Recent deals
- Dec 8, 2025Bluejay TherapeuticsStage unknownRiverVest Venture Fund V, L.P.source
05 · Latest from the firm
No news from the firm's website yet.
06 · Sources
- HTTP://WWW.RIVERVEST.COM
- https://rivervest.com/
- https://rivervest.com/about/
- https://rivervest.com/news/
- https://rivervest.com/team/
- https://rivervest.com/2025/12/09/portfolio-company-bluejay-therapeutics-to-be-acquired-by-mirum-pharmaceuticals/
Fund dates and sizes are from SEC Form D filings.
Last verified: Oct 25, 2026